Aim: The purpose of this study was to investigate The effectiveness of cognitive self-compassion on general health of woman headed households (somatization, anxiety, social dysfunction, depression) of Female Headed Households headed by Imam Khomeini Relief Committee. Method: The research method was semi-experimental with pretest-posttest design with control group. The statistical population of study included all the Female-headed households under coverage of the Imam Khomeini Relief Committee was formed in Rasht city in the second half 2015 year, That among them by using available, 30 female were selected and randomly assigned to the experimental group (15 individuals) and control group (15 individuals). The experimental group had received 8 sessions of Cognitive Self-Compassion Program. General Health questionnaire used to data gathering. Data were analyzed by multivariable co-variance test. Finding: Findings indicated that the research hypothesis of effect of Cognitive Self-Compassion Program on Mental Health (somatization, anxiety, social dysfunction, depression) of Female-headed households had been proven and Female-headed households of experimental group in comparison with control group, in posttest had a significantly less somatization, anxiety, social dysfunction, depression. Conclusion: So, we can conclude that Cognitive Self-Compassion Program has a significant effect on Mental Health of Female-headed households.