Abstract This study examined the effectiveness of Marlatt –based on cognitive-behavioral model on relapse reduction of opiate-dependents. In a pilot pretest – posttest with control group project, 30 opiate -dependent clients of addiction clinics in Khorramabad were randomly assigned to two groups. Experimental group were on 12 sessions of cognitive behavioral therapy, totally 24 hours but the control group did not receive any special treatment. All study participants at the beginning of study and end of the weekly meetings were tested by urinalysis. For data analysis, descriptive statistics and test were used. The results showed that the relapse rate of control group after the fourth week was significantly higher than the control group. According to the findings, it can be concluded that Marlatt-based on cognitive behavioral treatment model is effective on relapse reduction of opiate-dependents. :
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