The purpose of this study was the effectiveness of Cognitive Behavior Therapy on reducing the rate of depression and rumination in women that suffering from chronic fatigue syndrome. The statistic population in this study consisted of all females who referred to the health and clinical centers in Tabriz city and suffered from Chronic Fatigue Syndrome. 30 female patients were selected and randomly replaced into two groups. The instruments of this research were Chalder fatigue scale (CFS), Beck Depression Inventory (BDI) and Rumination Response Questionnaire (RSQ) . The results showed that there is significant effect of Cognitive Behavior Therapy on reducing depression in the women. Additionally, the results obtained from Rumination Response Questionnaire indicated that, the effect of Cognitive Behavior Therapy on reducing the obsessive rumination in subjects was significant. Therefore, it can be claimed that Cognitive Behavior Therapy’s effect on reducing obsessive rumination was to some extent more than reducing depression. Furthermore, it can be deduced that Cognitive Behavior Therapy effect on decreasing of depression and obsessive rumination by means of changing people’s interpretation of situations and changing attention of patients with chronic fatigue syndrome.
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